heart failure can change the structure of your heart, so it may not work as well. entresto helps improve your heart's ability to pump blood to the body. don't take entresto if pregnant; it can cause harm or death to an unborn baby. don't take entresto with an ace inhibitor or aliskiren, or if you've had angioedema with an ace or arb. the most serious side effects are angioedema, low blood pressure, kidney problems, or high blood potassium. ♪the beat goes on ask your doctor about entresto for heart failure. ask your doctor about entresto for heart failure yeah! entrust your heart to entresto. ♪the beat goes on