Share: Twilio Inc (NYSE: TWLO) shares gained more than 12% on Tuesday on the strength of some bullish analyst commentary from Wall Street. The Twilio Analyst: Jefferies analyst Samad Samana initiated coverage of Twilio with a Buy rating and $451 price target. The Twilio Thesis: Samana said Twilio has been successfully disrupting the communication space for several years now. He said Twilio should be able to maintain impressive growth numbers even as the business scales up. Since 2016, Twilio has generated about 60% compound annual revenue growth, and Samana said the company should continue to grow at above a 30% annual rate through at least 2023.