Ultrasound Offers Focused Noninvasive Option for Neuropsychiatric Disorders Noninvasive focused ultrasound stimulation with cell-type specificity. Source: College of Engineering, Carnegie Mellon University May 7, 2021 Share Neuromodulation, a therapeutic approach used in the treatment of neurological disorders such as Parkinson’s disease, epilepsy, and insomnia, delivers controlled physical energy to the patient’s nervous system. However, currently used clinical neuromodulation techniques are either invasive, such as deep brain stimulation where electrodes must be implanted into the brain, or unfocused, such as transcranial current stimulation where electrodes are placed on the head. Scientists now report a precise, noninvasive, and reversible neuromodulation technology that transmits low-intensity transcranial focused ultrasound (tFUS) pulses through the skull with high spatial resolution and selectivity at targeted brain regions that can be tuned to activate or deactivate neural circuits.