Share this article EMERYVILLE, Calif., April 21, 2021 /PRNewswire/ -- Dynavax Technologies Corporation (Nasdaq: DVAX), a biopharmaceutical company focused on developing and commercializing novel vaccines, today announced Valneva SE has initiated a pivotal Phase 3 clinical trial for its inactivated, COVID-19 vaccine candidate, VLA2001, using Dynavax's CpG 1018 adjuvant. The Phase 3 trial "Cov-Compare", (VLA2001-301), will compare Valneva's SARS-CoV-2 vaccine candidate, VLA2001, against AstraZeneca's conditionally approved vaccine, Vaxzevria, in a comparative immunogenicity trial. The initiation of the Cov-Compare trial follows positive initial results from Valneva's Phase 1/2 clinical trial, which demonstrated that the safety profile and immunogenicity were supportive of further development. , Chief Executive Officer of Dynavax commented: "We are excited to see the rapid initiation of the comparative Phase 3 clinical trial, providing an opportunity for Valneva's inactivated whole virus vaccine candidate adjuvanted with CpG 1018 to demonstrate superior immunogenicity with respect to the comparator. We are proud to be collaborating with Valneva on the development of this vaccine for COVID-19 and are committed to supporting Valneva in making the vaccine available."