Read Time: Efforts to enhance the ability of proteins to resist breaking down, or âdenaturingâ, at high temperatures is one of the hottest topics in biotech. Researchers have now identified some of the principles behind how this works, potentially opening up a raft of industrial applications for designer proteins. Bioengineers have found why proteins that are designed from scratch tend to be more tolerant to high temperatures than proteins found in nature. Natural proteins with high âthermostabilityâ are prized for their wide range of applications, from baking and paper-making to chemical production. Efforts to enhance protein thermostabilityâand to discover the principles behind thisâis one of the hottest topics in biotech.