With Its Final Ending, The Binding Of Isaac Crawls Out Of The Poop At Last Share Filed to:afterbirth Image: Binding of Isaac The Binding Of Isaac is the most successful video game ever made about a small child committing suicide by asphyxiating in a box. Neither part of the above statement is hyperbole. Nearly a decade after its September 2011 launch, Isaac remains one of the most successful indie games of all time, spawning merch lines, a card game, and an entire sub-genre iterating on its ideas about player persistence and death. And it is, undeniably, a game about a very young child who feels so alienated by his hyper-religious mother that he crawls into a box and dies. You don’t have to take our word for it, either; here’s designer Edmund McMillen discussing the game’s story with us back in 2019: