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Greenbacker Delivers Second Quarter Results
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Dollar Bank Three Rivers Arts Festival moves concerts from Byham Theater to Point State Park
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Researchers find potential target for oral cancer therapy
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A new Boston University School of Public Health (BUSPH) study has identified for the first time how the aryl hydrocarbon receptor (AhR), an environmental chemical receptor, drives immunosuppression in oral squamous cell carcinoma (OSCC) and that its removal from malignant cells can result in tumor rejection.
Published in the journal
Proceedings of the National Academy of Sciences, the study findings provide new insight into the biology of cancer immunosuppression, and identify a new target for cancer immunotherapy treatment.
Immune checkpoint inhibitors (immunotherapy drugs) are some of the most important treatments that have emerged for treating many cancers, including OSCC. Targeting immune checkpoint molecules such as PD-1, PD-L1 and CTLA4 has demonstrated that immunosuppression plays a significant role in OSCC pathology. But immune checkpoint inhibitors are only effective for about 30 percent of cancer patients, so there is a critical need for researchers to identi
Alabama vaccine distribution worst in the nation
Updated Jan 17, 2021;
Today’s guest columnist is Frank McPhillips.
When a deadly pandemic collides with exponential growth, the result is frightening. We have reached that point in Alabama, and we must speed up the distribution of vaccines.
During October, roughly 30,000 Alabamians contracted COVID-19. By November, the number rose to 42,500 in one month. In December, the number of cases more than doubled to 111,000. And, January’s cases are rising even faster than December’s.
As of this writing (January 12), more than 400,000 Alabamians have contracted the virus since the first official case on March 12, and the death toll stands at 5,347. It’s not easy to comprehend the magnitude of 400,000 cases. That is virtually equivalent to every man, woman and child living in Mobile County, our second most populous county. No other state with our population has witnessed nearly so many cases.