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JNCCN Study: Important Potential Role for Routine Brain Imaging in Advanced Kidney Cancer


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PLYMOUTH MEETING, Pa., April 13, 2021 /PRNewswire/  The April 2021 issue of
JNCCN Journal of the National Comprehensive Cancer Network publishes new research from Memorial Sloan Kettering Cancer Center (MSK) and Gustave Roussy Institute, which suggests that baseline brain imaging should be considered in most patients with metastatic kidney cancer. The researchers studied 1,689 patients with metastatic renal cell carcinoma (mRCC) who had been considered for clinical trial participation at either of the two institutions between 2001 and 2019 and had undergone brain imaging in this context, without clinical suspicion for brain involvement. The researchers discovered 4% had asymptomatic brain metastases in this setting. This group was found to have a low median 1-year overall survival rate (48%), and median overall survival (10.3 months). ....

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Changing the paradigm: Microbiome modulation may become the next 'pillar' in cancer treatment

Changing the paradigm: Microbiome modulation may become the next 'pillar' in cancer treatment
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United States , San Diego , Jennifera Wargo , Rob Knight , University Of California , University Of Texas Md Anderson Cancer Center , Chinese University Of Hong Kong , American Association Of Cancer Research , Cancer Therapy , American Association , Cancer Research , Microbiome Innovation , Cancer Genome Atlas , Microbiomei Centre , Chinese University , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , கொள்ளை நைட் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , சீன பல்கலைக்கழகம் ஆஃப் ஹாங் காங் , அமெரிக்கன் சங்கம் ஆஃப் புற்றுநோய் ஆராய்ச்சி , புற்றுநோய் சிகிச்சை , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி , புற்றுநோய் மரபணு அட்லஸ் ,

JNCCN Study: Important potential role for routine brain imaging in advanced kidney cancer

Researchers identify surface protein as a new osteosarcoma therapeutic target for antibody-drug conjugates


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IMAGE: A preclinical study shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using.
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Credit: MD Anderson Cancer Center
Abstract #LB008
HOUSTON A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using precision therapy targeting of cell-surface proteins through a Bicycle toxin conjugate (BTC), shows encouraging results for the treatment of osteosarcoma. ....

United States , Gemma Mudd , Eric Earley , Rossana Lazcano Segura , Pooja Hingorani , Philip Huxley , Raushan Kurmasheva , Edwarda Kolb , Zhaohui Xu , Nemours Alfred , Johanna Lahdenranta , Alexander Lazar , Richard Gorlick , Sankaranarayanan Kannan , Wendong Zhang , Sylvester Jusu , Peter Houghton , Douglas Harrison , Stephen Erickson , Yifei Wang , Tara Gelb , Jonathan Gill , Malcolma Smith , Zhachui Xu , Jing Wang , Zhongting Zhang ,