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The immune link between a leaky blood-brain barrier and schizophrenia


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IMAGE: A genetic condition known as 22q.11.2 deletion syndrome is associated with an increased risk of schizophrenia. A Penn Vet-led team found that a leaky blood-brain barrier, allowing inappropriate immune involvement.
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Credit: Courtesy of Jorge Iván Alvarez
Like a stern bodyguard for the central nervous sytem, the blood-brain barrier keeps out anything that could lead to disease and dangerous inflammation at least when all is functioning normally.
That may not be the case in people with schizophrenia and other mental disorders, suggest new findings from a team led by researchers from the School of Veterinary Medicine, Perelman School of Medicine, and Children s Hospital of Philadelphia (CHOP). In these individuals, a more permissive barrier appears to allow the immune system to get improperly involved in the central nervous system, the researchers showed. The inflammation that arises likely contributes to the clinical manifestati ....

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The FINANCIAL - With impressive accuracy, dogs can sniff out coronavirus


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The FINANCIAL  Many long for a return to a post-pandemic “normal,” which, for some, may entail concerts, travel, and large gatherings. But how to keep safe amid these potential public health risks?
According to University of Pennsylvania, one possibility, according to a new study, is dogs. A proof-of-concept investigation published today in the journal PLOS ONE suggests that specially trained detection dogs can sniff out COVID-19-positive samples with 96% accuracy.
“This is not a simple thing we’re asking the dogs to do,” says Cynthia Otto, senior author on the work and director of the University of Pennsylvania School of Veterinary Medicine Working Dog Center. “Dogs have to be specific about detecting the odor of the infection, but they also have to generalize across the background odors of different people: men and women, adults and children, people of different ethnicities and geographies.” ....

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