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Research reveals two phases of infection in patients with severe COVID-19 pneumonia

Research reveals two phases of infection in patients with severe COVID-19 pneumonia
What does SARS-CoV-2, the virus that causes COVID-19, do once it enters a person s airways, and how does infection in lung cells affect patients immune responses? New research led by investigators at Massachusetts General Hospital (MGH) and published in Nature Communications provides insights that could help improve treatment strategies for infected patients.
To analyze SARS-CoV-2 at the tissue level, the scientists examined autopsied material from 24 patients who succumbed to COVID-19.
We used a method called RNA in situ hybridization to visualize the actual SARS-CoV-2 virus in human lung specimens. This assay is now a clinical test being used at MGH to understand what tissues can be infected by the virus. ....

United States , Emily Henderson , Nature Communications , Cancer Center , Professor Of Medicine At Harvard Medical School , Massachusetts General Hospital , Associate Clinical Director , Mass General Cancer Center , Assistant Professor , Harvard Medical , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , புற்றுநோய் மையம் , ப்ரொஃபெஸர் ஆஃப் மருந்து இல் ஹார்வர்ட் மருத்துவ பள்ளி , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , இணை மருத்துவ இயக்குனர் , நிறை ஜநரல் புற்றுநோய் மையம் , உதவியாளர் ப்ரொஃபெஸர் , ஹார்வர்ட் மருத்துவ ,

Investegate |NOVARTIS AG CHF0.50(REGD) Announcements | NOVARTIS AG CHF0.50(REGD): Novartis announces positive FDA Advisory Committee recommendation for use of Entresto® to treat patients with HFpEF

NOVARTIS AG CHF0.50(REGD)
Novartis announces positive FDA Advisory Committee recommendation for use of Entresto® to treat patients with HFpEF
Novartis announces positive FDA Advisory Committee recommendation for use of Entresto® to treat patients with HFpEF
The Committee voted 12 to 1 that the data presented support the use of Entresto in treatment of patients with heart failure with preserved ejection fraction (HFpEF)
Potential Q1 2021 sNDA approval could make Entresto the first therapy indicated for use in treatment of patients with both major types of chronic heart failure: HFpEF and HFrEF; and the only chronic heart failure treatment studied in both conditions against active comparators ....

New York , United States , Eric Althoff , Isabella Zinck , David Soergel , Thomas Hungerbuehler , Coll Cardiol , Samir Shah , Scott Solomon , Sloan Simpson , Phil Mcnamara , American Heart Association , Committee Co , Advisory Committee , Novartis External Communications , Metabolic Drug Development , Metabolism Communications , Us Department Of Health , Human Services , Renal Drugs Advisory Committee , Drug Administration , Professor Of Medicine At Harvard Medical School , Novartis Us External Communications , Exchange Commission , Novartis Pharmaceuticals Corp , Hf New York Heart Association ,

Novartis announces positive FDA Advisory Committee recommendation for use of Entresto® to treat patients with HFpEF

Novartis announces positive FDA Advisory Committee recommendation for use of Entresto® to treat patients with HFpEF
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New York , United States , Eric Althoff , Isabella Zinck , David Soergel , Thomas Hungerbuehler , Coll Cardiol , Samir Shah , Scott Solomon , Sloan Simpson , Phil Mcnamara , American Heart Association , Committee Co , Novartis External Communications , Metabolic Drug Development , Metabolism Communications , Us Department Of Health , Human Services , Renal Drugs Advisory Committee , Drug Administration , Professor Of Medicine At Harvard Medical School , Novartis Us External Communications , Exchange Commission , Novartis Pharmaceuticals Corp , Hf New York Heart Association , New Drug Application ,

Novartis International AG: Novartis announces positive FDA Advisory Committee recommendation for use of Entresto to treat patients with HFpEF

(2)
The Committee voted 12 to 1 that the data presented support the use of Entresto in treatment of patients with heart failure with preserved ejection fraction (HFpEF)
Potential Q1 2021 sNDA approval could make Entresto the first therapy indicated for use in treatment of patients with both major types of chronic heart failure: HFpEF and HFrEF; and the only chronic heart failure treatment studied in both conditions against active comparators
1,2
HFpEF patients currently have no approved treatment options and face worsening symptoms that result in frequent HF hospitalizations, emergency room and urgent office visits
1,3,4
Basel, December 16, 2020 - Novartis today announced that the US Food and Drug Administration (FDA) Cardiovascular and Renal Drugs Advisory Committee (CRDAC) voted 12 to 1 that the data presented support the use of Entresto ....

New York , United States , Eric Althoff , Isabella Zinck , David Soergel , Thomas Hungerbuehler , Coll Cardiol , Samir Shah , Scott Solomon , Sloan Simpson , Phil Mcnamara , American Heart Association , Committee Co , Novartis External Communications , Metabolic Drug Development , Metabolism Communications , Us Department Of Health , Human Services , Renal Drugs Advisory Committee , Drug Administration , Professor Of Medicine At Harvard Medical School , Novartis Us External Communications , Exchange Commission , Novartis Pharmaceuticals Corp , Hf New York Heart Association , New Drug Application ,

Novartis announces positive FDA Advisory Committee recommendation for use of Entresto to treat patients with HFpEF

Posted December 16th, 2020 for Novartis
The Committee voted 12 to 1 that the data presented support the use of Entresto in treatment of patients with heart failure with preserved ejection fraction (HFpEF)
Potential Q1 2021 sNDA approval could make Entresto the first therapy indicated for use in treatment of patients with both major types of chronic heart failure: HFpEF and HFrEF; and the only chronic heart failure treatment studied in both conditions against active comparators
1,2
HFpEF patients currently have no approved treatment options and face worsening symptoms that result in frequent HF hospitalizations, emergency room and urgent office visits
1,3,4
Basel, December 16, 2020 Novartis today announced that the US Food and Drug Administration (FDA) Cardiovascular and Renal Drugs Advisory Committee (CRDAC) voted 12 to 1 that the data presented support the use of Entresto ....

New York , United States , Coll Cardiol , David Soergel , Scott Solomon , American Heart Association , Committee Co , Renal Drugs Advisory Committee , Human Services , Drug Administration , Professor Of Medicine At Harvard Medical School , Metabolic Drug Development , Exchange Commission , Us Department Of Health , Novartis Pharmaceuticals Corp , Hf New York Heart Association , New Drug Application , Harvard Medical School , Global Head , New York Heart Association , Drug Evaluation , Biologics Evaluation , Englj Med , American Heart , Rev Cardiol , Social Activity Limitations ,