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Republican incumbent Sen. John Hoeven, who voted in favor of the $1 trillion infrastructure bill, aims for a 3rd term against engineer Katrina Christiansen.
Corpus Christi-native Guajardo aims to fend off a challenger who listed a UPS store as his residential address in his application to run for mayor.
Republican Sen. Mike Crapo faces off against Democratic challenger David Roth in ruby-red Idaho.
Trump-endorsed John Boozman aims to fend off Democrat Natalie James to represent Arkansas in the US Senate for a 3rd term.
Polls close in the state at 8 p.m. Eastern Standard Time.