"Conotoxin modulation of ion channels in pain pathways" by Anuja Roy Bony
Pain which is an unpleasant sensory and emotional experience incorporating substantial tissue damage, remains quite unexplored in terms of chronic pain treatment due to availability and over prescription of opioid analgesics. These opioid drugs modulate the inhibitory signaling through coupling with G protein-coupled receptors (GPCR) (-opioid receptor), modulating a variety of ion channels and thus, resulting in inhibition of neurotransmitter release at the primary afferent nerve terminals in the spinal cord producing anti-nociception. However, the desired outcomes cannot outweigh the resul...
Source: uow.edu.au