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email article Enlarged fluid-filled spaces around cerebral small blood vessels were linked to cognitive decline, a prospective study of older adults showed. Severe perivascular space pathology in both the basal ganglia and the centrum semiovale, or in the centrum semiovale alone, was tied to a greater drop in global cognition over 4 years, reported Matthew Paradise, MBChB, MSc, of the University of New South Wales in Sydney, Australia, and co-authors. Large perivascular space dilation in both brain regions was an independent predictor of dementia across 8 years of follow-up (adjusted OR...

In the inaugural issue of the journal Nature Aging a research team led by aging expert Linda P. Fried, MD, MPH, dean of Columbia University Mailman School of Public Health, synthesizes converging evidence that the aging-related pathophysiology underpinning the clinical presentation of phenotypic frailty (termed as "physical frailty" here) is a state of lower functioning due to severe dysregulation of the complex dynamics in our bodies that maintains health and resilience. When severity passes a threshold, the clinical syndrome and its phenotype are diagnosable. This paper summarizes the evid...

According to new research in the journal Occupational & Environmental Medicine, people are likely to become more sedentary as they age, because retirement generally brings changes to daily routines and social interactions. No matter your age, it’s important to find an activity you love that you can do regularly and that you view as part of your everyday habits—like running. Despite plenty of alarm bells over the past few years about the risks of sedentary behavior, a new study suggests many older people aren’t heeding that wake-up call. Research, published in the journal Occupationa...