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IMAGE: Katherine Shield (from left), Dahlia An, Tyler Bailey at Lawrence Berkeley National Laboratory on Tuesday, November 17, 2020, in Berkeley, Calif.
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Credit: Marilyn Sargent/Berkeley Lab
A promising approach to treating cancer - called targeted alpha-particle therapy or TAT - could better harness the curative power of radiation treatments and lessen the severity of their more debilitating side effects.
TAT recruits drugs containing radioactive materials called alpha-emitting radioisotopes or radionuclides combined with cell-targeting molecules like antibodies. As alpha-emitting radioisotopes decay, they emit radiation in the form of highly energetic particles called alpha particles. Cell-targeting antibodies guide these alpha-emitting radioisotopes, like super-tiny guided missiles, to their final destination: cancer cells. ....

United States , Los Alamos , Kellen Obrien , Stosh Kozimor , Michael Fassbender , Meiring Nortier , Rebecca Abergel , Eva Birnbaum , Jim Oneil , Tyler Bailey , Frankie White , Veronika Mocko , Andrew Lakes , Etienne Vermeulen , Stacey Gauny , Sara Thiemann , Jonathan Engle , Lee Bernstein , Jason Cooley , Mark Brugh , University Of California , Los Alamos Neutron Science Center , Los Alamos National Laboratory , Office Of Science , Berkeley Lab Molecular Biophysics , National Accelerator Laboratory ,