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Higher doses of a second-generation antipsychotic are associated with an increased risk of dying in young adults aged 18-24 years, results of a large retrospective cohort study showed.
The lifespan of schizophrenia patients is significantly shorter than the general population. Olanzapine is one of the most commonly used antipsychotic drugs (APDs) for treating patients with psychosis, including schizophrenia and bipolar disorder. Despite their effectiveness in treating positive and negative symptoms, prolonged exposure to APDs may lead to accelerated aging and cognitive decline, among other side effects. Here we report that dysfunctional mitophagy is a fundamental mechanism underlying accelerated aging induced by olanzapine, using in vitro and in vivo (Caenorhabditis elegans)...
Real-world primary care data indicate that use of antipsychotics and antibiotics, among other meds, can significantly increase the risk of sudden cardiac arrest among people with type 2 diabetes.
Sanjai Rao, MD, shared best practices for utilizing long-acting injectable antipsychotics at the 2023 Psychiatric Times World CME Conference.
While use of atypical antipsychotics is rising, a new study found that the drugs are not safer than haloperidol for managing postoperative delirium in elderly patients.