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Our gut-brain connection - ScienceBlog.com

Our gut-brain connection
January 31, 2021MIT
“Organs-on-a-chip” system sheds light on how bacteria in the human digestive tract may influence neurological diseases.
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases.
Modeling these complex interactions in animals such as mice is difficult to do, because their physiology is very different from humans’. To help researchers better understand the gut-brain axis, MIT researchers have developed an “organs-on-a-chip” system that replicates interactions between the brain, liver, and colon. ....

Sarkis Mazmanian , Martin Trapecar , Linda Griffith , Rudolf Jaenisch , Koch Institute , National Cancer Institute , National Institute Of Environmental Health Sciences , National Institutes Of Health , Whitehead Institute , National Institute Of Biomedical Imaging , School Of Engineering Professor Teaching Innovation , Whitehead Institute For Medical Research , Army Research Office Institute For Collaborative Biotechnologies , Engineering Professor , Teaching Innovation , Medical Research , National Institutes , National Institute , Biomedical Imaging , Environmental Health Sciences , Koch Institute Support , Army Research Office Institute , லிண்டா கிரிஃபித் , கோச் நிறுவனம் , தேசிய புற்றுநோய் நிறுவனம் , தேசிய நிறுவனம் ஆஃப் சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் ,

Our gut-brain connection

Massachusetts Institute of Technology
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases.
Modeling these complex interactions in animals such as mice is difficult to do, because their physiology is very different from humans’. To help researchers better understa nd the gut-brain axis, MIT researchers have developed an “organs-on-a-chip” system that replicates interactions between the brain, liver, and colon.
Using that system, the researchers were able to model the influence that microbes living in the gut have on both healthy brain tissue and tissue samples derived from patients with Parkinson’s disease. They found that short-chain fatty acids, which are produced by microbes in the gut and are transported to the brain ....

Sarkis Mazmanian , Martin Trapecar , Linda Griffith , Rudolf Jaenisch , Koch Institute , National Cancer Institute , National Institute Of Environmental Health Sciences , National Institutes Of Health , Whitehead Institute , National Institute Of Biomedical Imaging , School Of Engineering Professor Teaching Innovation , Whitehead Institute For Medical Research , Army Research Office Institute For Collaborative Biotechnologies , Engineering Professor , Teaching Innovation , Medical Research , National Institutes , National Institute , Biomedical Imaging , Environmental Health Sciences , Koch Institute Support , Army Research Office Institute , லிண்டா கிரிஃபித் , கோச் நிறுவனம் , தேசிய புற்றுநோய் நிறுவனம் , தேசிய நிறுவனம் ஆஃப் சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் ,