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1. Progression-free survival was significantly greater among patients in the pembrolizumab group compared to placebo (10.0 vs. 8.1 months). 2. 1% of patients in each group experienced treatment-related mortality. Evidence Rating Level: 1 (Excellent) Study Rundown: Limited evidence exists on combined PD-1 and HER2 blockade with chemotherapy in HER2-positive gastro-esophageal cancer. This randomized controlled trial

1. Low-dose amitriptyline was associated with a marked decrease in IBS-SSS score at 6 months compared to placebo. 2. There were 5 serious adverse reactions (2 in the amitriptyline group and 3 in the placebo group). Evidence Rating Level: 1 (Excellent) Study Rundown: Irritable bowel syndrome (IBS) is a functional disorder that is managed through dietary changes

1. Low-dose amitriptyline was associated with a marked decrease in IBS-SSS score at 6 months compared to placebo. 2. There were 5 serious adverse reactions (2 in the amitriptyline group and 3 in the placebo group). Evidence Rating Level: 1 (Excellent) Study Rundown: Irritable bowel syndrome (IBS) is a functional disorder that is managed through

GEORGE TOWN (Nov 17): Allegations of the unity government’s involvement in the defection of Parti Pribumi Bersatu Malaysia (Bersatu) lawmakers could ultimately undermine the ruling coalition if proven to be true, according to political experts. Universiti Sains Malaysia political analyst Prof Ahm

Results from the phase 3 ATLANTIS study showed amitriptyline was superior to placebo across multiple symptom-based outcomes for patients with IBS.