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Novel monoclonal antibodies NA8 and NE12 can neutralize most SARS-CoV-2 variants and Omicron subvariants

Researchers generated and characterized two monoclonal antibodies (NA8 and NE12) that target the receptor binding domain of the SARS-CoV-2 spike protein, and exhibit neutralizing activity against major SARS-CoV-2 variants of concern. ....

United States , Lab Diagnostics Automation , Lab Diagnostics Automation Industry , Cell Reports , Corona Borealis , Automation Industry Focus , Image Credit , North American , Coronavirus Disease Covid 19 , Ars Cov 2 , Binding Affinity , Covid 19 , N Vivo , Monoclonal Antibody , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Spike Protein ,

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

A new study aimed to analyze the molecular interactions between the hCypA protein and the SARS-CoV-2 variants to determine the impact of variants on the blocking and binding potential of the hCypA–S protein complex with the ACE2 receptor. ....

United States , Cyclophilin Cyp , World Health Organization , Drug Administration , Cyclophilina Mediated , United States Food , Translational Medicine , Human Igg , Coronavirus Disease Covid 19 , Ars Cov 2 , Binding Affinity , Covid 19 , Hepatitis C , Japanese Encephalitis , Public Health , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Scientists computationally restore the potency of an antibody against SARS-CoV-2 Omicron subvariants

A team of researchers from the United States computationally modified the COV2-2130 monoclonal antibody to restore its neutralizing ability against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants, while retaining efficacy against the Delta and wild-type strains. ....

United States , Wa Hydrogen , Lab Diagnostics Automation , Lab Diagnostics Automation Industry , Automation Industry Focus , Coronavirus Disease Covid 19 , Ars Cov 2 , Binding Affinity , Covid 19 , Machine Learning , Monoclonal Antibody , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Bovine ultralong complementarity-determining region H3 found to cross-react with Sarbecoviruses

In a new study, researchers performed an in vitro analysis to isolate ultralong bovine heavy chains that showed binding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses (CoVs). ....

Andrii Yarovsky Shutterstock , Biological Chemistry , Genomics Industry Focus , Covs Pseudotyped , Middle East , Binding Affinity , N Vitro , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

PSI researchers optimize a method for tumor diagnosis using radionuclides

Researchers at the Paul Scherrer Institute PSI, in collaboration with ETH Zurich, have optimized a method for tumor diagnosis using radionuclides. ....

Viola Vogel , Emily Henderson , Paul Scherrer Institute , Laboratory Of Applied Mechanobiology , Centre For Radiopharmaceutical Sciences , Pharmacology Group , Radiopharmaceutical Sciences , Applied Mechanobiology , Binding Affinity , Medicinal Chemistry ,