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MCJ protein at the heart of new options to manage pulmonary hypertension

Researchers at the Spanish National Center for Cardiovascular Research (CNIC) have identified a new target that may open new avenues into pulmonary hypertension (PH) treatment. Their findings were published in Science Advances on Jan. 19, 2024. ....

Cardiovascular Research , Spanish National Center , Science Advances , Bioworld Science , Pulmonary Hypertension , Spanish National Center For Cardiovascular Research ,

CAR T cells could slow aging by eliminating senescent cells

CAR T cells could be repurposed to target senescent cells and delay the effect of aging. A study by scientists at Cold Spring Harbor Laboratory showed how to design them and demonstrated the advantages of this therapy in mice. “We only gave one dose, and we could have benefits [for] really long periods of time,” lead author Corina Amor told BioWorld. ....

Corina Amor , Cold Spring Harbor Laboratory , Bioworld Science , Senescent Cells , Drug Design , Rug Delivery And Technologies , Car T ,

Ultrarare transmitted Alzheimer's cases give clues to common forms

Investigators have identified five cases of so-called iatrogenic Alzheimer’s disease (AD), that is, AD that was acquired as a result of undergoing medical procedures. A team led by University College London scientists reported their findings online in Nature Medicine on Jan. 29, 2024. ....

University College London , Nature Medicine , Alzheimers Disease , Amyloid β , Prion Disease , Neurology Psychiatric , Bioworld Science ,

Self-propelled nanobots can deliver drugs to bladder, other tumors

Researchers from the Institute for Bioengineering of Catalonia (IBEC) and collaborators have successfully treated bladder tumors in mice using urease-powered nanobots. The testing consisted of the administration of 18F-nanorobots to tumor-bearing mice divided into four groups depending on tumor volumes using a group of non-tumor-bearing mice as control. Importantly, the therapy remained in the bladder with only a very small proportion of radioactivity seen in other organs. The results were published in Nature Nanotechnology on Jan. 15, 2024. ....

Institute For Bioengineering Of Catalonia , Nature Nanotechnology , Bioworld Science , Bladder Cancer , Nanobots Therapeutics Sl , Urease Powered Nanorobots , Drug Design , Rug Delivery And Technologies ,

2024 Frontiers of Knowledge Award unfolds the chaperone story

The discovery of how proteins fold and what happens if they don’t, or do it wrong, has impacted medicine. Protein function and several pathologies depend on folding. Four scientists, Franz-Ulrich Hartl, Arthur Horwich, Kazutoshi Mori, and Peter Walter, revealed the role of chaperones in assisting proteins to acquire their correct structure and described a failure warning system, the unfolded protein response (UPR). For their studies, the researchers will receive the 2024 Frontiers of Knowledge Award in Biology and Medicine from the BBVA Foundation. ....

Arthur Horwich , Peter Walter , Kazutoshi Mori , Franz Ulrich Hartl , Knowledge Award , Bioworld Science , Unfolded Protein Response , Frontiers Of Knowledge Award , Neurology Psychiatric ,