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Study unveils novel bladder cancer diagnostic model based on key mitochondrial genes

A novel diagnostic model using machine learning (ML).

Scientific-reports , Bladder , Ladder-cancer , Ancer , Iagnostic , Enes , Ell , Ell-metabolism , Hemicals , Ene , Achine-learning

Young and Addicted

could be around 20ml. the hospital can offer a range of treatment and support but, in the most extreme cases, patients will have to have their bladders removed and reconstructed using part of their bowel. probably the youngest that comes here could be i9 and onwards, so very, very young patients. so, 19 and they're already having severe bladder issues? problems with ketamine, yeah. if we are offering major surgery to a person who's 2i, then the likelihood of having any sort of complications after that surgery is enormous. the treatments are life—changing. since we've started doing this a year ago, we've seen so many patients, and it feels like we're getting more and more and more. one thing i want to make people aware of is if they do come and see us, we're

Patients , Hospital , Support , Treatment , Bladders , Cases , Range , 20 , Ketamine , Bladder , Issues , Problems

Young and Addicted

i didn't know who he was any more. it must have been incredibly difficult to see him like that, knowing that wasn't really rian. no. it wasn't him. it wasn't him — it was the drugs talking. but i couldn't get through to him. no matter what i said to him, i literally could not get through to him. and we tried everything that we could to try and, you know, stop him from doing what he was doing. rian started to struggle with bladder issues as a result of his prolonged ketamine use and ended up going to rehab. he was walking into rehab like he was a 90—year—old man, like on a — with a walking stick or hunched over, and his legs were bowed. he looked really, really poorly. government figures show ketamine addiction has more than quadrupled since 2016 in england and wales and use is estimated to have more than doubled in that time. and with those under 25, it's more than tripled — a growing concern for the british association

Wasn-t , It-wasn-t-him , It , Matter , Everything , It-wasn-t , Drugs-talking , Rian , Bladder , Ketamine-use , Result , Issues

BBC News

BBC News
vimarsana.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from vimarsana.com Daily Mail and Mail on Sunday newspapers.

Horse-tranquilliser , Bbc-news , Top , Voice-over , Anaesthetic , News-stories , Programme , Headlines , Music , Party-drug , Dissociative-effect , Vibes

Young and Addicted

so we can see that the use is higher during weekends — on fridays, saturdays and sundays — which probably points to the use of ketamine in recreational settings. try them both, mate. it's now later in the night and we're back with chronic ket users beth and jay. what is the physical impact for you now of taking ketamine? i can't walk down the street. i can't walk 50m without either needing to sit down or needing to run to the toilet. when i first went to the doctors in urology, they had no idea. they said, "we don't know what's going on. "all we can tell you is that your bladder has shrunk." you could see on the camera screen ketamine floating amongst my urine. it did also cause a big growth, where they had to burn that away immediately. when it's sort of at its peak as well, i can't engage in any conversation.

Ketamine , Use , Which , Settings , Saturdays , On-fridays , Jay , Impact , Chronic-ket-users-beth , Mate , Taking-ketamine , Both

Young and Addicted

of urological surgeons. i think we've seen a huge explosion of young people taking ketamine, and that means that they come to see us with significant urinary symptoms. and these symptoms can include going to the toilet every hour or every half an hour. and what the ketamine does is it destroys the lining of the bladder, and that can have very serious consequences. we've noticed throughout the whole country — we always have discussions amongst other urologists — that there's a huge explosion. all of us have seen pockets in certain places, some very high use of ketamine, and lots of young patients with severe bladder problems that we would not see until patients are much older. as a result, they're now putting together a document to help other health professionals spot the signs of ketamine bladder. ketamine is really popular in bristol — so much so, there's even

Ketamine , People , Us , Explosion , Symptoms , Bladder , Country , Toilet , Half , Lining , Discussions , Consequences

Young and Addicted

i struggle to focus on anything. i can't work, i can't, um, yeah, i can't — i can't do anything. i can't feed myself or go and get a drink. yeah, it really disables you completely. this is what was coming out, these blood clots, after i had to have, like, an operation. but yet, it's still not enough to be able to stop you from using it, right? it does make you think. it does make you really consider it more. you think, "right, i do need help with this now. "and i do want to stop now." but then, a part of me thinks, what's — when i do stop ketamine, what have i got? my life's been about ketamine for the last nine years now. so, once that's gone, i feel like what do i really have left? you feel sort of lost, yeah. is that how you feel, then? that's how i can feel, and that's where my depression comes and that's when i start to think, well, i might as welljust keep on using, keep on using. and if i lose my bladder, i lose my bladder. if i lose my life, i lose my life. if i lose myself, i lose myself. and that's what makes me

Anything , Drink , I-can-t , Um , It , Blood-clots , Operation , Ketamine , Life , Part , Stop-ketamine , Lost

Young and Addicted

it does destroy your organs. it does destroy your bladder. we wasn't taught about it in school. i kind of wish in uk schools that they would teach children from a young age that this stuff — you stay away from these kind of chemicals. my hope now is to engage in some support groups. i have support workers now and doing something different, going to the gym, making my life better and that's the steps — the next steps for me. i'm hoping that, you know, i'll get back into work, get back into my career path, and one day being the person that has recovered from this really rubbish journey that i've been on. but the hope is there and it is going to happen. lam determined. i don't want this life for myself any more. you're doing it this time. yeah. no matter how much you think it's taken your life, how much you think you've got nothing left, you can always gain that back, so it's never too late to reach out for help.

Bladder , The-uk , Stuff , Kind , Age , Schools , Wish , Organs , Children , Chemicals , School , Something

Young and Addicted

are rare, but on the rise. in the uk, the numbers of drug—related deaths following ketamine use have more than doubled in the last ten years. so, this is our drug—testing room. unlike rian, pagan managed to get help and has recovered after a 12—year addiction to ketamine. at her worst, she was taking more than 10g a day. it wasn't a nice experience. i was sick, dizzy and, like, kind of blacked out, so it wasn't very nice. i don't know why i carried on, but i did. and then, i started injecting it into my muscles and then, that's when my bladder started to get bad. what's it like to look back now and think about your addiction when it was at its worst? i wanted to die, yeah. ijust didn't want to be alive any more. ididn't want to be in the world, in that pain, completely reliant on ketamine. i spent eight weeks in hospital and i kind of felt

Ketamine-use , The-uk , Deaths , Rise , Room , Numbers , Ten , Ketamine , Rian , Addiction , Kind , Help

Young and Addicted

a term, bristol bladder, to refer to the impact ketamine can have on the bladder if you take a lot of it. do you have anything to hand over from this morning? we've got quite a big nightlife scene and festival scene in bristol, and i know that's commonly where people would take drugs. why ketamine seems to be the drug of choice — it's cheap to buy. i think people don't realise that it has detrimental effects to the bladder, and i think it's viewed as sort of a safe drug by people, which evidence doesn't show it is. some hospitals are also setting up specialist clinics in urology departments. so, this will be a normal bladder size. a normal bladder could be a capacity of about 500ml. this is an example of a bladder in a ketamine patient. that's a very small bladder. i will say that capacity

It , Bladder , Lot , Anything , Bristol , Impact-ketamine , Term , Big-nightlife-scene-and-festival , Ketamine , People , Drug , Drugs