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Phosphodiesterase 5 inhibitors (eg, sildenafil, tadalafil) do not appear to reduce the risk of Alzheimer disease and related dementias, according to an NIH study.
Results from the National Institutes of Health's Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study show that sildenafil (Viagra) and tadalafil (Cialis) may not be suitable candidates for treating dementia.
DREAM study findings conflict with other recent data
Neurological diseases often begin with an inflammatory process and the degradation of the so-called myelin layer, which surrounds the nerve fibers (axons) like a protective insulating layer.
Transparent peer review is a relative newcomer and not widely used at present, but it has grown in popularity and is becoming an increasingly popular choice. The question is—why? This blog post takes a closer look at the transparent peer review process, its rise in popularity, and the challenges journals, reviewers and editors face with this model.