CRISPR Screen and Deep Sequencing Map DNA Repair Landscape Boosting Genome Editing Prospects
Although genome editing holds unprecedented promise in the treatment of diseases, one of the major obstacles is that existing technologies frequently result in unwanted mutations or can fail to introduce any changes at all. Now, a new resource called Repair-seq has been developed, and it allows scientists to investigate how the complex cellular DNA repair mechanisms influence the outcome of genome editing technologies. Repair-seq provides a starting point for further explorations of DNA repair pathways.
Source: genengnews.com