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Automated IR-Spectroscopy for Analysis of Protein Biopharmaceuticals May 5, 2021 Time: 8:00 am PT, 11:00 am ET, 17:00 CET Higher-order structure is an important critical quality attribute that correlates structure-function characteristics with safety and efficacy for protein biotherapeutics. Infrared (IR) spectroscopy has long been recognized as a powerful biophysical tool for determining protein secondary structure and monitoring dynamic structural changes. Structural analysis helps establish process and product knowledge, inform the impact of upstream (cell culture) and downstream (purific...

Super-Resolution Imaging of Chromatin Organization in Health and Disease May 11, 2021 Share Time: 8:00 am PT, 11:00 am ET, 17:00 CET Understanding how cells organize the array of components within their membranous confines can not only provide insight into essential homeostatic functions it can also shed light on disorganized regions within the cell that may be an underlying cause of disease. The mechanistic feat cells perform to orderly arrange their contents and package vast amounts of material into such small boundaries is nothing short of remarkable. For instance, human DNA is two meters...

In this GEN webinar, Dr. Eric Wang from Memorial Sloan Kettering Cancer Center will speak about his recent work on using CRISPR technologies, including single-cell multimodal CRISPR screening (also known as ECCITE-seq), to discover new regulators of leukemia differentiation and potential therapeutic targets for differentiation-based therapies in AML.

The State of Gene Therapy May 4, 2021 Time: 11:00 am PT, 2:00 pm ET Special Guests: James Wilson, MD, PhD (Perelman School of Medicine, University of Pennsylvania) Artur Padzik, PhD (AAV Production Manager, Biovian) Gene therapy has made tremendous strides over the past decade or so. The first approved drugs are on the market, and literally hundreds of trials are underway offering unprecedented hope to patients with rare, debilitating genetic disorders. Nevertheless, safety issues continue to swirl around the field as adverse events are reported in trials involving both lentivirus and AAV v...

Monitoring SARS-CoV-2 Variants in Switzerland April 26, 2021 Time: 8:00 am PT, 11:00 am ET, 17:00 CET Since the rollout of the various COVID-19 vaccines, optimism has been on the rise that the pandemic may be finally heading in the right direction. Yet, as all good scientists know, we must remain vigilant and stringent in monitoring variants for the SARS-CoV-2 virus. In recent months, many areas of the world have seen a rise in viral variants, many of which are more virulent and could potentially lead to breakthrough infections in vaccinated populations.  The emergence of the SARS-CoV-2 VOC...