SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development
SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development As efforts to find effective antivirals to combat the SARS-CoV-2-caused COVID-19 pandemic continue, a new study explores the viral enzyme PLpro, encoded in the nonstructural protein nsp3, and its inhibitors. The study appeared as a preprint on the bioRxiv* server in December 2020. The Nsp3 Protein The viral genome encodes 16 non-structural proteins, of which nsp3 is the largest. This is a membrane protein with multiple domains and is essential within the replication-transcription complex formed on the host membranes. It is ...
Source: news-medical.net