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Immune Cells in Cerebrospinal Fluid Predict Response of Brain Metastasis to Immunotherapy March 9, 2021 Studies by researchers at the Vall d’Hebron Institute of Oncology (VHIO), and the National Centre for Genomic Analysis-Centre for Genomic Regulation (CNAG-CRG), Barcelona, have demonstrated how immune cells that access the cerebrospinal fluid (CSF) of patients with brain metastases faithfully recapitulate the characteristics of the brain tumor immune cells, and could represent novel biomarkers of response to immune checkpoint inhibitor (ICI) therapy. The team used single-cell RNA sequenc...

Immune Cells in Brain Predict Response to Immunotherapy by Angela Mohan on  March 8, 2021 at 6:18 PM Immune cells accessing cerebrospinal fluid recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies, as per the study in Nature Communications, led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor. Immune checkpoint inhibitors including anti-PD1, anti-PD-L1, and anti-CTLA4, have shown significant clinical benefits in...