Study reveals why we lose fat, muscle during infection
Although infections can cause a variety of symptoms, one typical indication is the loss of fat and muscle, a process known as wasting. Salk researchers
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Although infections can cause a variety of symptoms, one typical indication is the loss of fat and muscle, a process known as wasting. Salk researchers
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Salk scientists discovered that 1) the wasting response to T. brucei infection in mice occurs in two phases, each regulated by different immune cells and 2) fat loss did not benefit the fight against infection, but muscle loss did. The findings inform the development of more effective therapeutics that spare people from wasting and increase our understanding of how wasting influences survival and morbidity across infections, cancers, chronic illnesses, and more.