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Purpose: Whether preexisting sarcopenia is an independent risk factor for cancer incidence remains unclear. Therefore, we performed this propensity score (PS)-matched (PSM) population-based cohort study to compare the incidence rate ratios (IRRs) of specific cancers between patients with and without sarcopenia. Patients and Methods: The patients were categorized into two groups according to the presence or absence of sarcopenia, matched at a 4:1 ratio. Results: PS matching yielded a final cohort of 77,608 patients (15,527 in the sarcopenia and 62,081 nonsarcopenia groups) eligible for further analysis. In our multivariate Cox regression analysis, compared with the nonsarcopenia group, the adjusted hazard ratio (aHR; 95% confidence interval (CI)) for cancer risk in the sarcopenia group was 1.277 (1.10 to 1.36; p < 0.001). Furthermore, the adjusted IRRs (95% CIs) for sarcopenia patients were pancreatic cancer 3.77 (1.79 to 4.01), esophageal cancer 3.38 (1.87 to 4.11), lung cancer ....

Yilan Xian , T Ai Pei , Wan Fang , School Of Medicine , Taipei Medical University , Department Of Anesthesiology , Division Of Radiation Oncology , Centers For Regional Anesthesia , People Hospital Of Zhengzhou University , Asia University , Department Of Hemato , College Of Medicine , Big Data Center , Department Of Healthcare Administration , Department Of Food Nutrition , Department Of Internal Medicine , Institute Of Business Administration , Health Science , Health Biotechnology , Fu Jen Catholic University , Hsu Medical Foundation , Perioperative Medicine , Zhengzhou University , Henan Provincial People , Wan Fang Hospital , Internal Medicine ,