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<p>The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer&rsquo;s. A study in the journal&nbsp;<em>Cell </em>finds that the&nbsp;build-up of these toxic proteins also&nbsp;influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialised structures which roam the cytoplasm and act like a clean-up crew which&nbsp;capture&nbsp;and hold&nbsp;onto protein aggregates,&nbsp;rendering them harmless.&nbsp;Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic&nbsp;proteins failed to complete the very earlies&nbsp;stages of development. The study presents a new frontier to explore the underlying mechanisms of&nbsp;poor oocyte quality, which is the leading cause of female infertility.</p>

Comunidad autonoma de catalunaGabriele zaffagniniMethod of researchCentre for genomic regulationGenomic regulationGroup leaderOocyte biologyCellular dormancyEndolysosomal vesicular assemblies