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 E-Mail (Philadelphia, PA) - Like a failing fuel pump that causes a loss of engine power in a car, a diseased heart can take a serious toll on the body's performance. For some patients, tasks like walking up a flight of stairs or walking across a room eventually turn into exhausting endeavors. This is because, over time, regardless of the underlying cause, heart damage typically progresses, owing to a constant barrage of oxidative stress and toxic lipids that alter heart cell energetics and, ultimately, the ability of the heart to function normally. Oxidative stress occurs when harmful oxyge...

December 17, 2020 The American Heart Association has released its annual top 10 list for leading cardiovascular-related research and “accomplishments” for 2020, offering the caveat that much of it took place in the shadow of COVID-19. The AHA has been compiling this list since 1996, a press release notes. 1)EXPLORER-HCM. Released at the virtual European Society of Cardiology (ESC) Congress 2020, this small trial in the setting of hypertrophic cardiomyopathy (just 251 patients) showed that the first-in-class myosin inhibitor mavacamten (MyoKardia), on top of medical therapy, significantly...

 E-Mail IMAGE: Researcher Mete Civelek, PhD, of the University of Virginia School of Medicine's Department of Biomedical Engineering and UVA's Center for Public Health Genomics. view more  Credit: Courtesy Civelek lab Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease. In addition to identifying gene variants that influence risk, they found that one gene in particular appears to have a protective effect. Doctors may be able to use the findings to identify people at high risk ...

UVA researchers identify genes that influence risk for common form of heart disease Dec 10 2020 Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease. In addition to identifying gene variants that influence risk, they found that one gene in particular appears to have a protective effect. Doctors may be able to use the findings to identify people at high risk and to develop better treatments and preventative interventions. Current drugs for coronary artery disease treat the risk factors, suc...