Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia?
Early in the COVID-19 pandemic, the RECOVERY trial showed that anti-inflammatory therapy with 6 mg daily dexamethasone improved survival in patients requiring oxygen supplementation.1 Additional anti-inflammatory therapy with either interleukin-6 (IL-6) inhibitors or the Janus kinase inhibitor baricitinib was later shown to provide further benefit to such patients.2,3 However, because IL-6 inhibitors and Janus kinase inhibitors might be less appropriate for some patients (eg, those who are pregnant or who have liver or kidney impairment) and are likely to be unavailable in some health-care sys...