"Nickel and palladium catalysed cross-coupling: Factors effecting the o" by Nicholas S.D. Solomon and Sinead T. Keaveney
Catalytic cross-coupling reactions are widely employed in organic synthesis, with state-of-the-art cross-coupling methodology permitting high selectivity, low catalyst loading, mild reaction conditions, and in certain cases, air and water tolerant, catalysis. An essential aspect of targeted and effective cross-coupling reaction design is having a detailed understanding of the reaction mechanism—in particular, how the precise mechanism and reaction rate can be influenced to achieve the desired reactivity. In this chapter, focus is on understanding the step at which the electrophile is introdu...
Source: uow.edu.au