Maculopathy caused by pentosan polysulfate
Pentosan polysulfate (PPS) is a mainstay for treatment of bladder pain associated with interstitial cystitis Interstitial cystitis is a chronic bladder disorder causing pelvic pain and urinary frequency or urgency, with an estimated prevalence of 2.7%–6.5% among adult women.1 Pentosan polysulfate may buffer the bladder epithelium against irritants and is the only oral medication approved by Health Canada for treatment of interstitial cystitis. 1 It is typically administered orally at a dose of 100 mg 3 times daily. Maculopathy is associated with longer duration of PPS use A large retrospect...
Source: cmaj.ca