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Self-Built Protein Coatings Could Improve Biomedical Devices

Engineers explore protein self-assembly as improved coating process
Fouling is a natural phenomenon that describes the tendency of proteins in water to adhere to nearby surfaces. It’s what causes unwanted deposits of protein to form during some food production or on biomedical implants, causing them to fail. Researchers at Rensselaer Polytechnic Institute are harnessing this process, which is typically considered a persistent challenge, to develop a versatile and accessible approach for modifying solid surfaces.
“The goal of this work is to develop a method that is tolerant of pretty much any material and geometry by which we can modify surfaces that are normally hard to modify,” said R. Helen Zha, an assistant professor of chemical and biological engineering and member of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer. She is leading this research with the support of a more than $592,000 National Science Foundation Faculty Early Care ....

Deepak Vashishth , R Helen Zha , Ryan Gilbert , National Science Foundation Faculty Early Career Development , Researchers At Rensselaer Polytechnic Institute , Rensselaer Polytechnic Institute , Interdisciplinary Studies , Professor Zha , தீபக் வஷிஷ்ட் , ரியான் கில்பர்ட் , தேசிய அறிவியல் அடித்தளம் ஆசிரிய ஆரம்ப தொழில் வளர்ச்சி , ஆராய்ச்சியாளர்கள் இல் ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , இடைநிலை ஆய்வுகள் , ப்ரொஃபெஸர் ழ ,

Scientists reprogram a common bacterium to make designer sugar-based drug

Scientists reprogram a common bacterium to make designer sugar-based drug
Envisioning an animal-free drug supply, scientists have -; for the first time -; reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published today in
Nature Communications, the researchers modified
E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.
Genetically engineered
E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules -; called sulfated glycosaminoglycans -;that are often used as drugs and nutraceuticals.. ....

Jonathan Dordick , Deepak Vashishth , Robert Linhardt , Mattheos Koffas , Emily Henderson , Nature Communications , Rensselaer Polytechnic Institute , Rensselaer Polytechnic , E Coli , தீபக் வஷிஷ்ட் , ராபர்ட் லின்ஹார்ட் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , ரென்சீலர் பாலிடெக்நிக் , ஏ கோலி ,

Researchers Engineer E. coli for Animal-Free Drug Manufacturing

Researchers Engineer E. coli for Animal-Free Drug Manufacturing
genengnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from genengnews.com Daily Mail and Mail on Sunday newspapers.

Jonathan Dordick , Deepak Vashishth , Robert Linhardt , Mattheos Koffas , Nature Communications , Rensselaer Polytechnic Institute , Rensselaer Polytechnic Institute Center , Rensselaer Polytechnic , Interdisciplinary Studies , தீபக் வஷிஷ்ட் , ராபர்ட் லின்ஹார்ட் , இயற்கை தகவல்தொடர்புகள் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் மையம் , ரென்சீலர் பாலிடெக்நிக் , இடைநிலை ஆய்வுகள் ,

Common bacteria modified to make designer sugar-based drug

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Credit: Rensselaer Polytechnic Institute
TROY, N.Y. Envisioning an animal-free drug supply, scientists have for the first time reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published today in
Nature Communications, the researchers modified E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.
Genetically engineered E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules called sulfated glycosaminoglycans that are often used as drugs and nutraceuticals.. ....

Jonathan Dordick , Robert Linhardt , Asher Williams , Abinaya Badri , Payel Datta , Adeola Awofiranye , Deepak Vashishth , Mattheos Koffas , Keith Fraser , Nature Communications , Rensselaer Polytechnic Institute , National Science Foundation Grant , Rensselaer Polytechnic , Biomedical Environmental Chemical Engineering , Medicine Health , Pharmaceutical Science , ராபர்ட் லின்ஹார்ட் , ஆஷர் வில்லியம்ஸ் , அபினய பேத்ரி , பாயேல் தத்தா , தீபக் வஷிஷ்ட் , கேய்ட் ஃப்ரேசர் , இயற்கை தகவல்தொடர்புகள் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , தேசிய அறிவியல் அடித்தளம் மானியம் , ரென்சீலர் பாலிடெக்நிக் ,

New cancer models mimic aspects of mechanical environment within the body

New cancer models mimic aspects of mechanical environment within the body
As cancer and tumor cells move inside the human body, they impart and are subject to mechanical forces.
In order to understand how these actions affect cancer cell growth, spread, and invasion, a team of engineers at Rensselaer Polytechnic Institute is developing new models that mimic aspects of the mechanical environment within the body, providing new insight into how and why tumors develop in certain ways.
In research published today in
Integrative Biology, a team of engineers from Rensselaer developed an in vitro in the lab lymphatic vessel model to study the growth of tumor emboli, collections of tumor cells within vessels that are often associated with increased metastasis and tumor recurrence. ....

Deepak Vashishth , Jonathan Kulwatno , Emily Henderson , Rensselaer Polytechnic Institute , Integrative Biology , Study Lead , Assistant Professor , Mechanical Engineering , Rensselaer Polytechnic , Interdisciplinary Studies , Breast Cancer , In Vitro , Inflammatory Breast Cancer , தீபக் வஷிஷ்ட் , எமிலி ஹென்டர்சன் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , ஒருங்கிணைந்த உயிரியல் , படிப்பு வழி நடத்து , உதவியாளர் ப்ரொஃபெஸர் , இயந்திர பொறியியல் , ரென்சீலர் பாலிடெக்நிக் , இடைநிலை ஆய்வுகள் , மார்பக புற்றுநோய் , இல் விட்ரோ , அழற்சி மார்பக புற்றுநோய் ,