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Credit: Source: IFJ PAN
Malignant tumour cells undergo mechanical deformation more easily than normal cells, allowing them to migrate throughout the body. The mechanical properties of prostate cancer cells treated with the most commonly used anti-cancer drugs have been investigated at the Institute of Nuclear Physics of the Polish Academy of Sciences in Cracow. According to the researchers, current drugs can be used more effectively and at lower doses.
In cancer, a key factor contributing to the formation of metastasis is the ability of the neoplastic cells to undergo mechanical deformation. At the Institute of Nuclear Physics of the Polish Academy of Sciences (IFJ PAN) in Cracow, research on the mechanical properties of cells has been conducted for a quarter of a century. The latest study, carried out in cooperation with the Department of Medical Biochemistry of the Jagiellonian University Medical College, concerned several drugs currently used in prostate cancer chemothe ....

Malgorzata Lekka , Andrzej Kubiak , Marian Smoluchowski Krak , Department Of Cell Biology , National Research Centre , Research Consortium , European Commission , Department Of Biophysical Microstructures , Institute Of Nuclear Physics , Biotechnology Of The Jagiellonian University , Henryk Niewodniczanski Institute Of Nuclear Physics , Academy Of Sciences , Cyclotron Centre Bronowice , University Of Milan Department Physics , Hr Excellence In Research , Nuclear Physics , Polish Academy , Medical Biochemistry , Jagiellonian University Medical College , Biophysical Microstructures , Cell Biology , Jagiellonian University , Henryk Niewodniczanski Institute , Central Europe , Leading National Research Centre , Laboratoryof Spectroscopic Imaging ,