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Researchers use SARS-CoV-2 to bioengineer universal vaccine platform


Researchers use SARS-CoV-2 to bioengineer universal vaccine platform
A team of scientists from the United States has recently developed a bioengineered bacteriophage T4 nanoparticle structure using CRISPR technology that can be used as a universal platform to produce vaccines. They used severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a model to develop the platform. The study is currently available on the
Design of T4-SARS-CoV-2 nanovaccine by CRISPR engineering. Engineered DNAs corresponding to various components of SARS-CoV-2 virion are incorporated into bacteriophage T4 genome. Each DNA was introduced into E. coli as a donor plasmid (a), recombined into injected phage genome through CRISPR-targeted genome editing (b). Different combinations of CoV-2 inserts were then generated by simple phage infections and identifying the recombinant phages in the progeny (c). For example, recombinant phage containing CoV-2 insert #1 (dark blue) can be used to infect C ....

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