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The road to SiC process control

Our selection of industry specific magazines cover a large range of topics. ....

Yole Group , Onto Innovation , Design Of Experiment , Process Of Record ,

"Optimizing the composition of gelatin methacryloyl and hyaluronic acid" by Alireza Talaei, Cathal D. O'Connell et al.

Hydrogel materials are promising candidates in cartilage tissue engineering as they provide a 3D porous environment for cell proliferation and the development of new cartilage tissue. Both the mechanical and transport properties of hydrogel scaffolds influence the ability of encapsulated cells to produce neocartilage. In photocrosslinkable hydrogels, both of these material properties can be tuned by changing the crosslinking density. However, the interdependent nature of the structural, physical and biological properties of photocrosslinkable hydrogels means that optimizing composition is typically a complicated process, involving sequential and/or iterative steps of physiochemical and biological characterization. The combinational nature of the variables indicates that an exhaustive analysis of all reasonable concentration ranges would be impractical. Herein, response surface methodology (RSM) was used to efficiently optimize the composition of a hybrid of gelatin-methacryloyl (GelMA) ....

Design Of Experiment , Diffusion Coefficient , Elatin Methacryloyl Gelma , Yaluronic Acid Methacryloyl Hama , Response Surface Methodology ,