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Targeting apoptosis in cancer therapy has become increasingly popular, and there has been an increasing debate on whether apoptosis should be one of the main targets of therapy in cancer management. This study demonstrates the definition of apoptosis, the signaling pathways, and the pathogenesis behind it. We also show the correlation between apoptosis and cancer and how cancer can evade apoptosis to develop resistance to therapy. In addition, we illustrate the efficacy of adding pro-apoptotic therapy to conventional radio-chemotherapy cancer treatment.

A systematic review was conducted using PubMed, PubMed Central (PMC), and ResearchGate, including papers written in English, focusing on adult and geriatric populations, in literature reviews, systematic reviews, and randomized controlled trials published in the last 25 years with relevance to the question.

Based on the findings of this review, we conclude that apoptosis is a very sophisticated programmed cellular deat ....

Robert Horvitz , Development Of Multiple Drug Resistance , Pubmed Central , Reporting Items , Systematic Reviews , Medical Subject Headings , Multiple Systematic Reviews , Narrative Review Articles , Randomized Controlled Trials , Preferred Reporting Items , Correlation With Cancer , Multiple Drug Resistance ,