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Multi-valent mRNA vaccines against monkeypox

In a paper published in Science China Life Sciences, a group of scientists presented their study to develop multi-valent mRNA vaccines against monkeypox enveloped viron (EV) or mature viron (MV) surface antigens, and examine their efficacy and mechanism of action. A dynamic immune response was observed with a robust IgG response and correlating neutralizing activity against vaccinia virus (VACV), in association with the multi-valency vaccines. The vaccines protected a mouse model from a lethal dose VACV challenge with the EV and MV antigens-combined vaccine offering the strongest protection. These findings provide insight into the protective mechanism of multi-valent mRNA vaccines, and support the development of effective and safe mRNA vaccines for enhanced protection against monkeypox virus outbreak. ....

Pei Hao , Technology Major , National Science , National Natural Science Foundation Of China , National Key Research , Institute Of Pharmacology , Development Program Of China , Chinese Academy Of Sciences , Science China Life Sciences , Chinese Academy Of Agricultural Sciences , Chinese Academy , Agricultural Sciences , Beijing Institute , Science China Life , World Health Organization , Technology Major Projects , Development Program , Priority Research Program , Shanghai Municipal Science , Technology Major Project , National Natural Science Foundation , China Life ,

Silver carp scale collagen found to reduce melanin production – China study

Silver carp scale collagen found to reduce melanin production – China study
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