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Diffusing alpha-emitters radiation Therapy (DaRT) is an interstitial brachytherapy technique using 224Ra seeds. For accurate treatment planning a good understanding of the early DNA damage due to α-particles is required. Geant4-DNA was used to calculate the initial DNA damage and radiobiological effectiveness due to α-particles with linear energy transfer (LET) values in the range 57.5–225.9 keV/μm from the 224Ra decay chain. The impact of DNA base pair density on DNA damage has been modelled, as this parameter varies between human cell lines. Results show that the quantity and complexity...

The National Cancer Institute (NCI) has awarded a 5-year, $2.7 million grant to researchers at Sanford Burnham Prebys to investigate and elucidate the underlying cellular mechanisms that drive the most common form of breast cancer.

Study described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.

Researchers described the dual role of cell cycle and apoptosis regulator 2 (CCAR2) in cancer progression as a tumor suppressor and promoter.

Beachgoers are familiar with the experience of spending hours in the sun, going home, and noticing only hours later that their skin has changed color.