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"Methods and applications of single-molecule fluorescence microscopy" by Stefan H. Mueller - Vimarsana News

"Methods and applications of single-molecule fluorescence microscopy" by Stefan H. Mueller

The molecular mechanisms that support life depend on the fate of small populations of molecules. The functions of biomolecules, however, are traditionally characterised through bulk-phase biochemical methods that only report on ensemble averages. Such methods are not sensitive to population heterogeneity or short-lived reaction intermediates. Single-molecule methods that allow for the direct observation of individual molecules have significantly advanced our understanding of biology in the past two decades. The goal of the work described in this PhD thesis was the development and use of single...

Source: uow.edu.au
Discovery of novel pathway offers a potential solution for preventing cancer chemo-resistance - Vimarsana News

Discovery of novel pathway offers a potential solution for preventing cancer chemo-resistance

Researchers have uncovered a novel pathway that explains how cancer cells become resistant to chemotherapies, which in turn offers a potential solution for preventing chemo-resistance.

Common molecular tool for DNA labelling shows unexpected anticancer properties - Vimarsana News

Common molecular tool for DNA labelling shows unexpected anticancer properties

Scientists at the UNC School of Medicine have made the surprising discovery that a molecule called EdU, which is commonly used in laboratory experiments to label DNA, is in fact recognized by human cells as DNA damage, triggering a runaway process of DNA repair that is eventually fatal to affected cells, including cancer cells.

Rice University researchers model a key mechanism by which DNA replicates - Vimarsana News

Rice University researchers model a key mechanism by which DNA replicates

Knowing the structure of a complex biological system isn't nearly enough to understand how it works. It helps to know how the system moves.

Research progress on the three-dimensional interaction between virus and host genome - Vimarsana News

Research progress on the three-dimensional interaction between virus and host genome

A recent study reviewed the current progress on 3D interactions between host and viral genomes.