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MS Mouse Study Links Cortical Inflammation to Immune Cell Destruction

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Multiple sclerosis (MS)-associated inflammation in the cerebral cortex the outermost layer of the brain that is involved in cognitive function prompts the destruction of neural connections by specific immune cells, according to a study in a mouse model of MS.
These immune cells targeted dendritic spines (nerve cell communication structures) containing abnormally high levels of calcium a dysregulation previously associated with nerve fiber degeneration in MS.
Importantly, blocking the activation of these immune cells, called phagocytes, successfully prevented the loss of cerebral cortex synapses (sites of neural communication) in the mice, highlighting that similar approaches may help prevent disease progression in people with MS. ....

Marta Figueiredo , Martin Kerschensteiner , Doron Merkler , Thomas Misgeld , Technical University Of Munich , University Of Lisbon , Leiden University Medical Center , University Of Geneva , Biomedical Sciences , Clinical Neuroimmunology , Ludwig Maximilians University Munich , Technical University , Developmental Biology , Medical Microbiology , Infectious Diseases , Applied Biology , Instituto De Medicina Molecular , மார்த்தா பிகுேய்ரேதோ , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , பல்கலைக்கழகம் ஆஃப் லிஸ்பன் , பல்கலைக்கழகம் ஆஃப் ஜிநீவ , உயிர் மருத்துவ அறிவியல் , லுட்விக் அதிகபட்சம் பல்கலைக்கழகம் முனிச் , தொழில்நுட்ப பல்கலைக்கழகம் , வளர்ச்சி உயிரியல் , மருத்துவ நுண்ணுயிரியல் ,

Immune cells attack synapses

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Immune cells attack synapses
Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. A team of neuroscientists has now shown that the cause are inflammatory responses that lead to synapse loss, reducing neuronal activity. Targeted inhibition of these immune cells could mitigate such synaptic damage, and therefore provides a promising therapeutic option for progressive multiple sclerosis.
Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, in which nerve cells are attacked by the patient’s own immune system. In many cases, the disease develops into a progressive form, which is characterized by a shift of pathology from the white matter to the gray matter, for instance to the cerebral cortex. This phase of the disease has so far been difficult to treat and its underlying causes are poorly understood. ....

Em Ullrich Gavilanes , Doron Merkler , Thomas Misgeld , University Of Geneva , Neuronal Cell Biology , Ullrich Gavilanes , எம் உள்ல்றிச் கவிலானேச் , பல்கலைக்கழகம் ஆஃப் ஜிநீவ , உள்ல்றிச் கவிலானேச் ,

Multiple sclerosis: Immune cells silence neurons by removing synapses

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Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity.
Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, in which nerve cells are attacked by the patient s own immune system. In many cases, the disease develops into a progressive form, which is characterized by a shift of pathology from the white matter to the gray matter, for instance to the cerebral cortex. This phase of the disease has so far been difficult to treat and its underlying causes are poorly understood. Now, a research team led by Martin Kerschensteiner, Director of the Institute for Clinical Neuroimmunology at LMU, in cooperation with Thomas Misgeld (Technical University of Munich) and Doron Merkler (University of Geneva), has shown in a mouse model that inflammation of t ....

Martin Kerschensteiner , Doron Merkler University Of Geneva , Thomas Misgeld Technical University Of Munich , Institute For Clinical Neuroimmunology , Clinical Neuroimmunology , Thomas Misgeld , Technical University , Doron Merkler , தொழில்நுட்ப பல்கலைக்கழகம் ,