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Editorial Article: Targeting protein-protein interactions (PPIs): Identifying PPI inhibitors for novel therapeutics Dr. David Andrews, AstraZeneca, discusses the future of small-molecule drug discovery for PPIs 20 Apr 2021 Dr. David Andrews, Director of Pre-Clinical Scientific Alliances, AstraZeneca Proteins control a variety of intra- and extracellular biological processes and when sequenced or expressed and activated incorrectly can increase the likelihood of disease. Protein-protein interactions (PPIs) are fundamental in the stable running of cellular processes where they can alter the kinetic properties of enzymes, create new binding sites, inactivate proteins, and change the specificity of a protein. PPIs can be manipulated by small molecules that can change the outcome of a variety of different cellular processes. The inhibition of these cellular processes can prevent diseases, therefore, inhibiting PPIs is becoming increasingly attractive for novel therape ....