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Hyperinflammatory conditions drive gender differences in COVID-19 severity and mortality Coronavirus disease 2019 (COVID-19) is a highly contagious disease characterized by respiratory failure and death in severe conditions. It is caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, in late 2019. COVID-19 is associated with many inflammatory conditions such as macrophage activation and cytokine storm triggered by increased production of interleukins, C-reactive protein (CRP), and tumor necrosis factors-α (TNF-α). Coagulopathy and renal and liver inflammation have been reported to increase the mortality risk in severe COVID-19 patients. Evidence from other studies suggests that COVID-19 causes more deaths in males than females. ....