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Study elucidates the role of two isoforms of KRAS oncogenes

Study elucidates the role of two isoforms of KRAS oncogenes
KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumors. The development of KRAS inhibitors is, thus, an extremely active line of research. Effective results have been elusive so far, though - no KRAS inhibitor had been available until a month ago, when the FDA granted approval to Sotorasib.
KRAS encodes two gene products, KRAS4A and KRAS4B, whose levels can vary across organs and embryonic stages. When KRAS mutates, both variants, or isoforms, are activated. Though, some studies have focussed on approaches to target only KRAS4B, since it usually found to be expressed at higher levels in tumors. ....

Mariano Barbacid , Eduardo Caleiras , Marina Salm , Matthias Drosten , Sagrario Ortega , Guillem Paniagua , Emily Henderson , Autonomous Community Of Madrid , Institute Of Health Carlos , Experimental Oncology Group , Spanish Ministry Of Science , European Research Council , Research Fund , Experimental Oncology Programme , Oncology Group , Mouse Genomic Editing Core Unit , Score Unit , Histopathology Core Unit , Spanish Ministry , Health Carlos , Autonomous Community , எமிலி ஹென்டர்சன் , தன்னாட்சி சமூக ஆஃப் மாட்ரிட் , நிறுவனம் ஆஃப் ஆரோக்கியம் கார்லோஸ் , சோதனை புற்றுநோயியல் குழு , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் ,

CNIO researchers clarify the role of the two isoforms of KRAS, the most common oncogene in humans

CNIO researchers clarify the role of the two isoforms of KRAS, the most common oncogene in humans
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Mariano Barbacid , Eduardo Caleiras , Marina Salm , Matthias Drosten , Sagrario Ortega , Guillem Paniagua , Autonomous Community Of Madrid , Institute Of Health Carlos , Experimental Oncology Group , Spanish Ministry Of Science , European Research Council , Research Fund , Experimental Oncology Programme , Oncology Group , Mouse Genomic Editing Core Unit , Score Unit , Histopathology Core Unit , Spanish Ministry , Health Carlos , Autonomous Community , தன்னாட்சி சமூக ஆஃப் மாட்ரிட் , நிறுவனம் ஆஃப் ஆரோக்கியம் கார்லோஸ் , சோதனை புற்றுநோயியல் குழு , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் , ஐரோப்பிய ஆராய்ச்சி சபை , ஆராய்ச்சி நிதி ,

CNIO researchers clarify role of two isoforms of KRAS, most common oncogene in humans

CNIO researchers clarify role of two isoforms of KRAS, most common oncogene in humans
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Mariano Barbacid , Marina Salm , Matthias Drosten , Guillem Paniagua , Experimental Oncology Group , Experimental Oncology Programme , Oncology Group , சோதனை புற்றுநோயியல் குழு , புற்றுநோயியல் குழு ,