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Obesity, High BMI Linked to Greater MS Risk, Autoimmune Activity 3.7 (21) Obesity and a higher body mass index (BMI) are associated with both increased multiple sclerosis (MS) risk and harmful autoimmune activity that is induced by leptin, a hormone secreted by fat cells, a study finds. These results indicate that leptin, which helps regulate body weight, may act as a functional link between obesity and MS. The worldwide prevalence of MS has increased over the past years, and previous studies have found a potential association between BMI and the risk of developing the d...

MSC-NPs are seen as a possible way of treating people with progressive MS, who have few effective disease-modifying treatments available. They are essentially stem cells collected from a patient’s bone marrow that are expanded and matured to produce factors involved in modulating the immune response and in nervous tissue growth and survival. An open-label Phase 1 trial (NCT01933802) investigated this stem cell treatment  in 20 adults with stable primary (four PPMS patients) or secondary progressive MS (16 SPMS patients) and significant disability.   All received a total of three inje...