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University at Buffalo Study: Memory deficits resulting from epigenetic changes in Alzheimer’s disease can be reversed In preclinical study, researchers have identified new genes that could be key therapeutic targets for treating Alzheimer’s disease Zhen Yan, PhD, SUNY Distinguished Professor, Department of Physiology and Biophysics Jacobs School of Medicine and Biomedical Sciences BUFFALO, N.Y. – Memory loss associated with Alzheimer’s disease (AD) may be able to be restored by inhibiting certain enzymes involved in abnormal gene transcription, according to a preclinical study by r...

Zhen Yan, SUNY Distinguished Professor Department of Physiology and Biophysics Memory loss associated with Alzheimer’s disease (AD) may be able to be restored by inhibiting certain enzymes involved in abnormal gene transcription, according to a preclinical study by UB researchers. The findings could pave the way toward new treatments for Alzheimer’s disease. The paper was published Dec. 9 in Science Advances. “By treating AD mouse models with a compound to inhibit these enzymes, we were able to normalize gene expression, restore neuronal function and ameliorate cognitive impairment,” ...