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"Sleep apnea multi-level surgery trial: long-term observational outcome" by Alison J. Pinczel, Charmaine M. Woods et al.

Study Objectives: The sleep apnea multi-level surgery (SAMS) randomized clinical trial showed surgery improved outcomes at 6 months compared to ongoing medical management in patients with moderate or severe obstructive sleep apnea (OSA) who failed continuous positive airway pressure therapy. This study reports the long-term outcomes of the multi-level surgery as a case series. Methods: Surgical participants were reassessed >2 years postoperatively with the same outcomes reported in the main SAMS trial. Primary outcomes were apnea-hypopnea index (AHI) and Epworth sleepiness scale (ESS), with secondary outcomes including other polysomnography measures, symptoms, quality of life, and adverse events. Long-term effectiveness (baseline to long-term follow-up [LTFU]) and interval changes (6 month to LTFU) were assessed using mixed effects regression models. Control participants were also reassessed for rate of subsequent surgery and outcomes. Results: 36/48 (75%) of surgical participants w ....

Cohort Studies , Follow Up Studies , Patient Satisfaction , Sleep Apnea , Leep Surgical Procedures , Urveys And Questionnaires , Treatment Outcome ,

Pediatric Cancer Survivors Treated With Abdominopelvic RT Have Higher Risk of CRC

Pediatric cancer survivors treated with abdominopelvic region radiotherapy have an increased risk of colorectal cancer, a study suggests. Pediatric cancer survivors treated with abdominopelvic region radiotherapy have an increased risk of colorectal cancer, a study suggests. ....

Pancare Childhood , Adolescent Cancer Survivor Care , Follow Up Studies ,

Pediatric Cancer Survivors Treated With Abdominopelvic RT Have Higher Risk of CRC

Pediatric cancer survivors treated with abdominopelvic region radiotherapy have an increased risk of colorectal cancer, a study suggests. Pediatric cancer survivors treated with abdominopelvic region radiotherapy have an increased risk of colorectal cancer, a study suggests. ....

Pancare Childhood , Adolescent Cancer Survivor Care , Follow Up Studies ,

Patterns of mean-level change in personality traits across the life course: a meta-analysis of longitudinal studies

The present study used meta-analytic techniques (number of samples = 92) to determine the patterns of mean-level change in personality traits across the life course. Results showed that people increase in measures of social dominance (a facet of extraversion), conscientiousness, and emotional stabil … ....

Pmid 16435954 , Oi 10 1037 0033 2909 132 1 , Meta Analysis , Research Support , N Ih , On Us Gov X27 T , Brentw Roberts , Atee Walton , Wolfgang Viechtbauer , Follow Up Studies , Ife Change Events , Pubmed Abstract , National Institutes Of Health , National Center For Biotechnology Information , National Library Of Medicine ,