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The Brain's Pleasure System Wastes Away in Early-Onset Dementia, Study Finds

18 APRIL 2021
Dementia is a thief that picks many pockets. In some guises, it takes our memories. Other forms rob us of inhibition. Sometimes it even takes away happiness itself.
A new study has shown for the first time how some forms of early-onset dementia are associated with a profound loss of pleasure linked to a wasting of hedonic hotspots – brain regions associated with reward seeking.

An absence of pleasure is known as anhedonia, and it s a common symptom in mental health conditions such as depression and obsessive-compulsive disorder. Where most of us are rewarded with a sense of satisfaction, excitement, and bliss when we achieve a goal or associate with loved ones, those experiencing anhedonia can t. ....

New South Wales , University Of New South Wales , University Of Sydney , Muireann Irish , புதியது தெற்கு வேல்ஸ் , பல்கலைக்கழகம் ஆஃப் புதியது தெற்கு வேல்ஸ் , பல்கலைக்கழகம் ஆஃப் சிட்னி ,

Landmark Study Identifies The Neurons Especially Vulnerable to Alzheimer's Disease

Landmark Study Identifies The Neurons Especially Vulnerable to Alzheimer s Disease
ELEFTHERIA KODOSAKI, THE CONVERSATION
19 JANUARY 2021
Alzheimer s disease is a devastating condition that is currently unstoppable and incurable. The main cause of the disease is the loss of neurons and other brain cells in the brain – also know as degeneration. This degeneration is what leads to problems with memory and other cognitive functions.

Researchers can tell which neurons die first or exhibit increased vulnerability to Alzheimer s disease based on where they re located in the brain and what they look like.
But they don t know what genes or proteins these neurons express. Knowing these factors is important for recognising and identifying the changes in specific cells that happen when disease is present. ....

Detailed text transcripts for TV channel - MSNBC - 20190526:03:51:00

And to think that was 40 years, that kind of comedy, those kind of issues, you probably couldn t do today. you certainly couldn t do it on a broadcast network. somewhere in some corner of net flex or hbo you could. i remember i was around 12 when it came on. i m sitting there watching it and even though i was not obviously evolved on politics, i knew having come from watching leave it to beaver , this was not your father s oldsmobile as far as television. you watch those other shows and it was so raw and frontal. it was just right out there. in a way, it was in keeping with the times because everything was changing and everything was very sort of present and vibrant and the conflict was out in the open. it wasn t buried. ....

Broadcast Network , Net Flex , Leave It To Beaver , Game Of Thrones , It Wasn T , The Open ,

Detailed text transcripts for TV channel - CNN - 20180913:00:11:00

He s up against. but we have to expect that water atlantic water is going to get over both the frontal and the primary dune and get to at least lake park. reporter: storm surge isn t the only threat. he has the local lake drained to accept what could be record-breaking rain. do you think all of that s going to be enough? i hope so. i know hope s not a not much of a game plan, but at this point in time, take every measure you can. reporter: there is another critical decision this weather commando has made. he s leaving. you don t see that as the captain abandoning his ship? no, you know, from my background in special operations with, yes, i can get the sense how that might read. reporter: but he also knows he told everyone to leave. it doesn t set a good example. reporter: what do you think you ll find when you come back? we re going to lose beach. and structural damage in the island. it s my hope that we can accept that and rebuild from that. but loss of life is ....

Storm Surge Isn T , Lake Park , The Rain , Game Plan , Joe Benson , Special Operations , Weather Commando , It Doesn T ,

Detailed text transcripts for TV channel - CNN - 20180913:04:11:00

reporter: this first-time politician has been in office less than a year and now has a disaster at his doorstep. did you ever anticipate that you would be mayor of a community that faces now a cataclysmic hurricane? not necessarily, although everyone who lives on the island, and most people you ll ask, they ll say that the risk of living in a beautiful place like carolina beach. reporter: he s no longer responsible for just his own family. he has 6,300 residents to look out for. you have any idea how many people have left? i would say about 75%. now, i know that 100% won t. reporter: with florence closing in, he takes a look around his community. the road will certainly be threatened, if not significantly underwater. reporter: like any commander before a fight, he assesses what he s up against. but we have to expect that water atlantic water is going to get over both the frontal and the primary dune and get to at least lake park. reporter: storm surge isn t the ....

Joe Benson , Carolina Beach , Won T , Florence Closing In , Storm Surge Isn T , Lake Park ,