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"A Monte Carlo study to evaluate and optimise the angular dependence of" by Ilia Filipev, Giordano Biasi et al.

Purpose: A detector assembly based on a 2D silicon array sensor, Octa, was previously demonstrated to be accurate for small field relative dosimetry. Experimental studies showed angular dependence of the response that has also variations with the field size. A Monte Carlo simulation model was developed and used in this work to study how the detector assembly's components contribute to the observed angular dependence. Methods: Geant4 was used as the Monte Carlo code. A detailed model of the Octa detector and its packaging was placed in the centre of a solid water phantom with the central sensitive volumes (SVs) located at the isocentre and irradiated at polar angles from 0 to 180° (the beam was normal to the detector plane at 0°). Phase-space files from the IAEA database were used to model a CyberKnife X-ray beam with collimator diameters of 5, 10, and 15 mm. Reference simulations were compared with previous experimental results. To investigate the impact of the assembly's m ....

Monte Carlo , Cyberknifex Ray , 2d Monolithic Silicon Array Detector , Angular Dependence , Monte Carlo Simulation , Mall ﬁeld Dosimetry , Stereotactic Ablative Body Radiotherapy ,

"Geant4 simulation model of electromagnetic processes in oriented cryst" by Alexei Sytov, Laura Bandiera et al.

Electromagnetic processes of charged particles interaction with oriented crystals provide a wide variety of innovative applications such as beam steering, crystal-based extraction/collimation of leptons and hadrons in an accelerator, a fixed-target experiment on magnetic and electric dipole moment measurement, X-ray and gamma radiation source for radiotherapy and nuclear physics and a positron source for lepton and muon colliders, a compact crystalline calorimeter as well as plasma acceleration in the crystal media. One of the main challenges is to develop an up-to-date, universal and fast simulation tool to simulate these applications. We present a new simulation model of electromagnetic processes in oriented crystals implemented into Geant4, which is a toolkit for the simulation of the passage of particles through matter. We validate the model with the experimental data as well as discuss the advantages and perspectives of this model for the applications of the oriented crystals ment ....

"The Development of Microdosimetric Instrumentation for Quality Assuran" by James Vohradsky

This thesis presents research for the development of new microdosimetric instrumentation for use with solid-state microdosimeters in order to improve their portability for radioprotection purposes and for QA in various hadron therapy modalities. Monte Carlo simulation applications are developed and benchmarked, pertaining to the context of the relevant therapies considered. The simulation and experimental findings provide optimisation recommendations relating to microdosimeter performance and possible radioprotection risks by activated materials.
The first part of this thesis is continuing research into the development of novel Silicon-on-Insulator (SOI) microdosimeters in the application of hadron therapy QA. This relates specifically to the optimisation of current microdosimeters, development of Monte Carlo applications for experimental validation, assessment of radioprotection risks during experiments and advanced Monte Carlo modelling of various accelerator beamlines.
Geant4 ....

Monte Carlo , Silicon On Insulator ,

"Accurate and Fast Deep Learning Dose Prediction for a Preclinical Micr" by Florian Mentzel, Jason Paino et al.

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumor diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Monte Carlo (MC) simulations are one of the most used methods at the Imaging and Medical Beamline, Australian Synchrotron to calculate the dose in MRT preclinical studies. The steep dose gradients associated with the 50 (Formula presented.) m-wide coplanar beamlets present a significant challenge for precise MC simulation of the dose deposition of an MRT irradiation treatment field in a short time frame. The long computation times inhibit the ability to perform dose optimization in treatment planning or apply online image-adaptive radiotherapy techniques to MRT. Much research has been conducted on fast dose estimation methods for clinically available treatments. However, such methods, including GPU Monte Carlo implementations and machine learning (ML) models, are un ....

Monte Carlo , Medical Beamline , Australian Synchrotron , Deep Learning , Lose Prediction , Microbeam Radiation Therapy , Monte Carlo Simulation , Preclinical Study ,

"Validation of the Geant4 PIXE component for incident carbon ions" by Samer Bakr, David D. Cohen et al.

The goal of this study is to experimentally validate PIXE modelling using the Geant4-ANSTO model (“G4-ANSTO”), distributed for the first time in Geant4 11.0, as well as the Geant4 default model (“G4-default”), for targets bombarded with carbon ions of energies up to 3 MeV/amu, an energy range of importance for PIXE applications. The experimental validation was performed using a variety of target materials, spanning a broad atomic number range. The reference experimental measurements were performed at the ANSTO heavy ion microprobe beamline ANTARES. To the authors’ knowledge, this is the first benchmarking investigation for PIXE simulations in Geant4 utilising carbon ions and it is significant for PIXE-based elemental analysis, encompassing archaeological samples, gas samples, environmental and planetary samples for geological and planetary research studies. It is also of relevance for any physics application, requiring the modelling of particle induced atomic de-excitation or ....

Carbon Ions , X Ray Fluorescence ,