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Gene Responsible For Longer Lifespan Helps Cope-Up Stress by Karishma Abhishek on  February 21, 2021 at 11:24 PM Nature Communications. Forkhead box protein O3 (FOXO3) . FOXO3, when exposed to oxidative stress, is involved in triggering programmed cell death (apoptosis) in the absence of survival factors, including neuronal cell death. Early studies done by the team suggest that lack of FOXO3 gene in the mice brain renders them incapable of coping up with stressful conditions in the brain, which leads to the progressive death of neurons. FOXO3 thus preserves the brain...

Melatonin Helps Boosts Memory In mice, melatonin and its metabolites were found to promote long-term memories and protect against cognitive decline, stated a new study conducted by Tokyo Medical and Dental University (TMDU) researchers in Japan. Cognitive decline in mice manifests as poor memory, and when tested on the novel object recognition task, the mice behave as if both objects are new. The research team was curious about the role of melatonin's metabolites in boosting memory and cognitive decline. ‘Melatonin and two of its metabolites help memories stick around in the brain and s...